Researchers discover why fructose doesn't satisfy hunger like glucose

A new study found that fructose and glucose may look the same on a nutrition label, but the brain treats them very differently. In mice, glucose strongly reduced activity in hunger-promoting brain cells, while fructose had a much weaker effect. High-fructose corn syrup triggered a stronger response and was preferred by the animals. The findings suggest that the type of sugar—not just the calories—can influence appetite and food preferences.